GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs2275426 | 1 | rs11579634 | chr1:46466391 | CCDC163P | chr1:45960581-45965646:- | 0.39 | 11.67 | 1.11E-29 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs11579634 | chr1:46466391 | MUTYH | chr1:45794915-45806142:- | -0.11 | -4.35 | 1.5E-5 | Body mass index |
| BRCA | cis | rs12134133 | 1 | rs11580382 | chr1:207418392 | C4BPA | chr1:207277511-207318308:+ | 0.15 | 4.41 | 1.12E-5 | Posterior cortical atrophy and Alzheimer's disease |
| BRCA | cis | rs12134133 | 1 | rs11580387 | chr1:207418408 | C4BPA | chr1:207277511-207318308:+ | 0.16 | 4.49 | 7.79E-6 | Posterior cortical atrophy and Alzheimer's disease |
| BRCA | cis | rs11799420 | 1 | rs11580415 | chr1:171666832 | VAMP4 | chr1:171669298-171711214:- | 0.12 | 3.48 | 0.000523 | Hippocampal atrophy |
| BRCA | cis | rs11799420 | 1 | rs11580522 | chr1:171720978 | VAMP4 | chr1:171669298-171711214:- | -0.25 | -7.17 | 1.37E-12 | Hippocampal atrophy |
| BRCA | cis | rs11799420 | 1 | rs11583920 | chr1:171683611 | VAMP4 | chr1:171669298-171711214:- | 0.19 | 5.57 | 3.15E-8 | Hippocampal atrophy |
| BRCA | cis | rs12196860 | 1 | rs115852057 | chr6:55983101 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.86 | 1.14E-11 | Psychosis (atypical) |
| BRCA | cis | rs11588062 | 1 | rs11588062 | chr1:46779764 | NSUN4 | chr1:46806390-46830690:+ | 0.18 | 4.3 | 1.87E-5 | Age-related hearing impairment (interaction) |
| BRCA | cis | rs2275426 | 1 | rs11589562 | chr1:46466721 | CCDC163P | chr1:45960581-45965646:- | 0.35 | 9.99 | 1.65E-22 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs11589562 | chr1:46466721 | GPBP1L1 | chr1:46092978-46152302:- | -0.12 | -3.53 | 0.000439 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs11589562 | chr1:46466721 | MUTYH | chr1:45794915-45806142:- | -0.15 | -5.81 | 8.15E-9 | Body mass index |
| BRCA | cis | rs11590090 | 1 | rs11590090 | chr1:113313563 | FAM19A3 | chr1:113263189-113269854:+ | 0.2 | 6.31 | 4.19E-10 | Hyperactive-impulsive symptoms |
| BRCA | cis | rs11590526 | 1 | rs11590526 | chr1:116427567 | TSPAN2 | chr1:115590635-115632115:- | 0.2 | 3.59 | 0.000341 | Educational attainment |
| BRCA | cis | rs11799420 | 1 | rs11590680 | chr1:171716574 | VAMP4 | chr1:171669298-171711214:- | 0.23 | 6.79 | 1.85E-11 | Hippocampal atrophy |